Mouse b-wave mutants

Comparisons of structural and functional abnormalities in mouse b-wave mutants.

In the most simplistic view, the retinal circuit can be divided into vertical excitatory pathways that use glutamate as their neurotransmitter and lateral inhibitory pathways in the outer and inner synaptic layers that modulate excitation via glycine and GABA. Within the vertical excitatory pathways, the visual signal is initiated in the rod, cone or both photoreceptors, depending on the adapta...

Acatalasemic and hypocatalasemic mouse mutants.

A strain of mice genetically deficient in blood catalase should be of considerable value in studying the possible role of hydrogen peroxide in carcinogenesis and cancerolysis, as suggested by WARBURG, AWEHN, and GEISSLER (1957) and by HOLMAN (1957), and in assessing the possible role of H,O, in radiation lethality. That such a strain could be viable appeared probable from the work of TAKAHARA (...

Mouse toxicity and cytokine release by verotoxin 1 B subunit mutants.

The crystal structure of the verotoxin 1 (VT1) B subunit complexed with a globotriaosylceramide (Gb(3)) analogue showed the presence of three receptor binding sites per monomer. We wished to study the effects of altering the three sites, singly or in combination, on animal toxicity and cytokine induction in vitro. We found that while the site 1 and 2 mutants were modestly (two- to sevenfold) re...

Molecular basis of mouse developmental mutants.

Mouse behavioral mutants have neuroimaging abnormalities.

Impaired cognitive, memory, or motor performance is a distinguishing characteristic of neurological diseases. Although these symptoms are frequently the most evident in human patients, additional markers of disease are critical for proper diagnosis and staging. Noninvasive neuroimaging methods have become essential in this capacity and provide means of evaluating disease and tracking progressio...